林焕彩 | 17c呱呱爆料

林焕彩

教授主任医师博士生导师硕士生导师

导师介绍

【学位 / 学历】

博士 / 博士研究生

【学术简历】

1979.09-1984.07??中山医科大学口腔临床医学专业获学士学位

1986.09-1989.07 ?中山医科大学口腔临床医学专业获硕士学位

1996.01-1998.12 ?香港大学口腔预防医学专业获博士学位

【研究方向】

1. 口腔流行病学

2. 龋病微生物学

【主持课题】

1.?2020-2023年：《笔补肠蛋白颁123段来源的淀粉样六肽抑制变异链球菌生物膜形成的机制研究》，国家自然科学基金，55万

2.?2021-2023年：《儿童乳牙龋风险预测模型的建立和验证项目》，中华口腔医学会，88.7万

3.?2023-2024年：《BZ 耀白满天星?精华牙膏去除牙齿外源性色素效果的临床研究》，横向合作，44.7万

【发表论文】

1.Chen Y, Huang Y, Lin H, Chen D. The effects and mechanisms of novel antibacterial amyloid peptides derived from Streptococcus mutans proteome. Chemical Engineering Journal. 2024 Apr; 497.

2.Wang W, Huang Y, Lin H, Cao Y. Role of opuB in Modulating Membrane Vesicle Composition and Function in Streptococcus mutans Under Neutral and Acidic Conditions. Microorganisms. 2025 Apr 11; 13(4):884.

3.Wang W, Lin H, Cao Y. Effects of opuB on the growth and biofilm formation of Streptococcus mutans under acid stress. Microb Pathog. 2025 May 6; 107674.

4.Weng L, Cui Y, Jian W, Zhang Y, Pang L, Cao Y, Zhou Y, Liu W, Lin H, Tao Y. Inter-kingdom interactions and environmental influences on the oral microbiome in severe early childhood caries. Microbiol Spectr. 2025 Apr 15: e0251824.

5.Zhang Y, Chen T, Gu L, Yuan R, Cao Y, Lin H, Zhi Q. Effect of the stability of the poly (gamma-glutamic acid)-ACP dispersion system on biomimetic mineralization of type I collagen. Biomater Sci. 2025 Jan 28;13(3):795-809.

6.Li P, Zhang Y, Chen D, Lin H. Investigation of a novel biofilm model close to the original oral microbiome. Appl Microbiol Biotechnol. 2024 May 10;108(1):330.

7.Wang Y, Wen J, Pan T, Cao Y, Lin H, Zhou Y. Comparing the effectiveness of caries arrest by micro-operative treatment to operative treatment: A 2-year randomized controlled clinical trial. Clin Oral Investig. 2024 Mar 19;28(4):222.?

8.Pang L, Zhou Y, Tao Y, Yu L, Cao Y, Lin H, Zhi Q. An experiential service-learning project on oral health examination and education. BMC Med Educ. 2024 Jan 5;24(1):34.

9.Pan T, Li Y, Liu FS, Lin H, Zhou Y. Membrane-Anchored Aggregation-Induced Emission Luminogens: Accurate Labeling and Efficient Photodynamic Inactivation of?Streptococcus mutans?in Anticaries Therapy. ACS Appl Mater Interfaces. 2024 Jun 19;16(24):30833-30846.

10.Wen J, Tao Y, Pang L, Cao Y, Lin H, Zhou Y. Parental Feeding Styles and Risk of a New Carious Lesion in Preschool Children: A Longitudinal Study. Nutrients. 2023 Oct 16;15(20):4387.

11.Weng L, Wen J, Cui G, Liang J, Pang L, Lin H. Comparison of modified bass, rolling, and current toothbrushing techniques for the efficacy of plaque control - A randomized trial. J Dent. 2023 Aug; 135:104571.

12.Huang Y, Wang T, Chen Y, Lin H, Chen D. Amyloid hexapeptide prevent dental caries by antibiofilm formation. J Dent. 2023 Aug; 135:104596.

13.Wang C, Wu J, Liu L, Xu D, Liu Y, Li S, Hou W, Wang J, Chen X, Sheng L, Lin H, Yu D. Improving osteoinduction and osteogenesis of Ti6Al4V alloy porous scaffold by regulating the pore structure. Front Chem. 2023 May 17; 11:1190630.

14.Cui Y, Chen D, Lin H, Tao Y. The association between low birth weight and/or preterm birth and dental caries -A systematic review and meta-analysis. Int J Dent Hyg. 2023 Aug;21(3):599-610.

15.Liang J, Zhou Y, Tang G, Wu R, Lin H. Exploration of the Main Antibiofilm Substance of?Lactobacillus plantarum?ATCC 14917 and Its Effect against?Streptococcus mutans. Int J Mol Sci. 2023 Jan 19;24(3):1986.

16.Zhou Y, Liu Z, Wen J, Zhou Y, Lin H. The inhibitory effect of berberine chloride hydrate on?Streptococcus mutans?biofilm formation at different pH values. Microbiol Spectr. 2023 Sep 25;11(5): e0217023.

17.Cui G, Li P, Wu R, Lin H. Streptococcus mutans membrane vesicles inhibit the biofilm formation of Streptococcus gordonii and Streptococcus sanguinis. AMB Express. 2022 Dec 12;12(1):154.

18.Chen D, Liu X, Chen Y, Lin H. Amyloid peptides with antimicrobial and/or microbial agglutination activity. Appl Microbiol Biotechnol. 2022 Dec;106(23):7711-7720.

19.Liang Y, Yao J, Qiu R, Chen A, Huang H, Lin H, Yu L. The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study. BMC Oral Health. 2022 Nov 5;22(1):471.

20.Pang L, Zhi Q, Jian W, Liu Z, Lin H. The Oral Microbiome Impacts the Link between Sugar Consumption and Caries: A Preliminary Study. Nutrients. 2022 Sep 7;14(18):3693.

21.Wang Y, Zhang Y, Pan T, Lin H, Zhou Y. Metabolic differences of the oral microbiome related to dental caries - A pilot study. Arch Oral Biol. 2022 Sep; 141:105471.

22.Pan T, Liu FS, Lin H, Zhou Y. Anti-biofilm studies of synthetic imidazolium salts on dental biofilm in vitro. J Oral Microbiol. 2022 May 17;14(1):2075309.

23.Wu R, Cui G, Cao Y, Zhao W, Lin H.?Streptococcus Mutans?Membrane Vesicles Enhance?Candida albicans?Pathogenicity and Carbohydrate Metabolism. Front Cell Infect Microbiol. 2022 Jul 26; 12:940602.

24.Chen Y, Cui G, Cui Y, Chen D, Lin H. Small molecule targeting amyloid fibrils inhibits Streptococcus mutans biofilm formation. AMB Express. 2021 Dec 17;11(1):171.

25.Cui Y, Wang Y, Zhang Y, Pang L, Zhou Y, Lin H, Tao Y. Oral Mycobiome Differences in Various Spatial Niches with and without Severe Early Childhood Caries. Front Pediatr. 2021 Nov 15;9:748656.

26.Su Q, Pang L, Zhou Y, Yu L, Lin H, Zhi Q. A two-week single-group longitudinal test of a new sonic-powered toothbrush simulating the 'bass brushing technique' with tapered bristles on the brush head for reduction of dental plaque and gingivitis. Int J Dent Hyg. 2021 Nov;19(4):398-406.

27.Pang L, Wang Y, Ye Y, Zhou Y, Zhi Q, Lin H. Metagenomic Analysis of Dental Plaque on Pit and Fissure Sites with and Without Caries Among Adolescents. Front Cell Infect Microbiol. 2021 Oct 27; 11:740981.?

28.Zhi Q, Si Y, Wang X, Tai B, Hu Y, Wang B, Zheng S, Liu X, Rong W, Wang W, Wang C, Feng X, Lin H. Determining the factors associated with oral health-related quality of life in Chinese elders: Findings from the fourth national survey. Community Dent Oral Epidemiol. 2022 Aug;50(4):311-320.?

29.Yu LX, Wang X, Feng XP, Tai BJ, Hu Y, Wang B, Wang CX, Zheng SG, Liu XN, Rong WS, Wang WJ, Si Y, Lin HC. The relationship between different types of caries and periodontal disease severity in middle-aged and elderly people: findings from the 4th National Oral Health Survey of China. BMC Oral Health. 2021 May 3;21(1):229.?

30.Cao Y, Lin H. Characterization and function of membrane vesicles in Gram-positive bacteria. Appl Microbiol Biotechnol. 2021 Mar;105(5):1795-1801.?

31.Chen D, Li J, Pan T, Wu R, Tao Y, Lin H. The broad-spectrum antibiofilm activity of amyloid-forming hexapeptides. Microb Biotechnol. 2021 Mar;14(2):656-667.?

32.Pang L, Wang K, Tao Y, Zhi Q, Zhang J, Lin H. A New Model for Caries Risk Prediction in Teenagers Using a Machine Learning Algorithm Based on Environmental and Genetic Factors. Front Genet. 2021 Mar 11; 12:636867.?

33.Li J, Chen D, Lin H. Antibiofilm peptides as a promising strategy: comparative research. Appl Microbiol Biotechnol. 2021 Feb;105(4):1647-1656.?

34.Su Q, Zhang C, Mai S, Lin H, Zhi Q. Effect of poly (γ-glutamic acid)/tricalcium phosphate (γ-PGA/TCP) composite for dentin remineralization in vitro. Dent Mater J. 2021 Jan 31;40(1):26-34.?

35.Chen Y, Chen D, Lin H. Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. BMC Oral Health. 2021 Jan 7;21(1):13.

36.Li Q, Li J, Feng Z, Lin H, Xu Q. Effect of histone demethylase KDM5A on the odontogenic differentiation of human dental pulp cells. Bioengineered. 2020 Dec;11(1):449-462.?

37.Cao Y, Zhou Y, Chen D, Wu R, Guo L, Lin H. Proteomic and metabolic characterization of membrane vesicles derived from Streptococcus mutans at different pH values. Appl Microbiol Biotechnol. 2020 Nov;104(22):9733-9748.?

38.Fan C, Guo L, Gu H, Huo Y, Lin H. Alterations in Oral-Nasal-Pharyngeal Microbiota and Salivary Proteins in Mouth-Breathing Children. Front Microbiol. 2020 Oct 9; 11:575550.?

39.Wu R, Tao Y, Cao Y, Zhou Y, Lin H.?Streptococcus mutans?Membrane Vesicles Harboring Glucosyltransferases Augment?Candida albicans?Biofilm Development. Front Microbiol. 2020 Sep 11; 11:581184.?

40.Yin L, Zhu W, Chen D, Zhou Y, Lin H. Small noncoding RNA sRNA0426 is involved in regulating biofilm formation in Streptococcus mutans. Microbiologyopen. 2020 Sep;9(9):e1096.

41.Li B, Pan T, Lin H, Zhou Y. The enhancing antibiofilm activity of curcumin on Streptococcus mutans strains from severe early childhood caries. BMC Microbiol. 2020 Sep 16;20(1):286.?

42.Wang K, Pang L, Fan C, Cui T, Yu L, Lin H. Enamel and Dentin Caries Risk Factors of Adolescents in the Context of the International Caries Detection and Assessment System (ICDAS): A Longitudinal Study. Front Pediatr. 2020 Jul 28; 8:419.

43.Pang L, Li X, Wang K, Tao Y, Cui T, Xu Q, Lin H. Interactions with the aquaporin 5 gene increase the susceptibility to molar-incisor hypomineralization. Arch Oral Biol. 2020 Mar; 111:104637.?

44.Wang K, Pang L, Tao Y, Li X, Zhang J, Cui T, Zeng B, Lin H. Association of genetic and environmental factors with dental caries among adolescents in south China: A cross-sectional study. Eur J Paediatr Dent. 2020 Jun;21(2):129-136.?

【参编教材与论着】

1.?2022年：主编《实用口腔流行病学》?人民卫生出版社 ISBN978-7-117-33860-8

2.?2020年：副主编《口腔预防医学（第7版）》?人民卫生出版社 ISBN978-7-117-29374-7

【获奖及学术荣誉】

1.?2021年广东省本科高校课程思政优秀案例二等奖

2.?2022年广东医师奖

3.?2023年中山大学第十一届校级本科教育教学成果二等奖

【社会兼职】

1.?中华口腔医学会口腔预防医学专业委员会前任主任委员

2.?中华预防医学会口腔卫生保健专业委员会主任委员

3.?广东省医师协会第叁届口腔医师分会委员会主任委员

4.?广东省医师协会副会长

5.?中华口腔医学会口腔医疗服务分会副主任委员

【联系方式】

地址：广东省广州市陵园西路56号

电话：020-83744816

邮箱：濒颈苍丑肠蔼尘补颈濒.蝉测蝉耻.别诲耻.肠苍

17c呱呱爆料

【研究方向】

1. 口腔流行病学

2. 龋病微生物学

【主持课题】

【发表论文】

1.Chen Y, Huang Y, Lin H*, Chen D*. The effects and mechanisms of novel antibacterial amyloid peptides derived from Streptococcus mutans proteome. Chemical Engineering Journal. 2024 Apr; 497.

2.Wang W, Huang Y, Lin H*, Cao Y*. Role of opuB in Modulating Membrane Vesicle Composition and Function in Streptococcus mutans Under Neutral and Acidic Conditions. Microorganisms. 2025 Apr 11; 13(4):884.

3.Wang W, Lin H*, Cao Y*. Effects of opuB on the growth and biofilm formation of Streptococcus mutans under acid stress. Microb Pathog. 2025 May 6; 107674.

4.Weng L, Cui Y, Jian W, Zhang Y, Pang L, Cao Y, Zhou Y, Liu W, Lin H*, Tao Y*. Inter-kingdom interactions and environmental influences on the oral microbiome in severe early childhood caries. Microbiol Spectr. 2025 Apr 15: e0251824.

5.Zhang Y, Chen T, Gu L, Yuan R, Cao Y, Lin H*, Zhi Q*. Effect of the stability of the poly (gamma-glutamic acid)-ACP dispersion system on biomimetic mineralization of type I collagen. Biomater Sci. 2025 Jan 28;13(3):795-809.

6.Li P, Zhang Y, Chen D*, Lin H*. Investigation of a novel biofilm model close to the original oral microbiome. Appl Microbiol Biotechnol. 2024 May 10;108(1):330.

7.Wang Y, Wen J, Pan T, Cao Y, Lin H*, Zhou Y*. Comparing the effectiveness of caries arrest by micro-operative treatment to operative treatment: A 2-year randomized controlled clinical trial. Clin Oral Investig. 2024 Mar 19;28(4):222.?

8.Pang L, Zhou Y, Tao Y, Yu L, Cao Y, Lin H*, Zhi Q*. An experiential service-learning project on oral health examination and education. BMC Med Educ. 2024 Jan 5;24(1):34.

9.Pan T, Li Y, Liu FS, Lin H*, Zhou Y*. Membrane-Anchored Aggregation-Induced Emission Luminogens: Accurate Labeling and Efficient Photodynamic Inactivation of?Streptococcus mutans?in Anticaries Therapy. ACS Appl Mater Interfaces. 2024 Jun 19;16(24):30833-30846.

10.Wen J, Tao Y, Pang L, Cao Y, Lin H*, Zhou Y*. Parental Feeding Styles and Risk of a New Carious Lesion in Preschool Children: A Longitudinal Study. Nutrients. 2023 Oct 16;15(20):4387.

11.Weng L, Wen J, Cui G, Liang J, Pang L*, Lin H*. Comparison of modified bass, rolling, and current toothbrushing techniques for the efficacy of plaque control - A randomized trial. J Dent. 2023 Aug; 135:104571.

12.Huang Y, Wang T, Chen Y, Lin H*, Chen D*. Amyloid hexapeptide prevent dental caries by antibiofilm formation. J Dent. 2023 Aug; 135:104596.

13.Wang C, Wu J, Liu L, Xu D, Liu Y, Li S, Hou W, Wang J, Chen X, Sheng L, Lin H*, Yu D*. Improving osteoinduction and osteogenesis of Ti6Al4V alloy porous scaffold by regulating the pore structure. Front Chem. 2023 May 17; 11:1190630.

14.Cui Y, Chen D, Lin H*, Tao Y*. The association between low birth weight and/or preterm birth and dental caries -A systematic review and meta-analysis. Int J Dent Hyg. 2023 Aug;21(3):599-610.